Launching September 2027

Hypothyroidism

Hypothyroidism At A Glance

  • Hypothyroidism, or an underactive thyroid, occurs when the thyroid gland does not produce enough thyroid hormone.
  • Low thyroid hormone levels slow many body functions, and symptoms often develop gradually over months or years.
  • Common symptoms include fatigue, weight gain, cold intolerance, dry skin, constipation, depression, slow heart rate, and hair thinning.
  • Hashimoto’s thyroiditis is the most common cause, but thyroid surgery, radioactive iodine treatment, certain medications, and other conditions can also lead to hypothyroidism.
  • Diagnosis usually relies on TSH and free T4 blood tests.
  • Treatment generally involves daily thyroid hormone replacement, most commonly levothyroxine, with regular blood testing to adjust the dose.

Table of Contents

Table of Contents

What Is Hypothyroidism?

Hypothyroidism, also called an underactive thyroid, is a condition in which the thyroid gland does not produce enough thyroid hormone. The thyroid is a small, butterfly-shaped gland located in the front of the neck that helps regulate your body’s metabolism, heart rate, body temperature, digestion, and energy levels.

When thyroid hormone levels are too low, many of the body’s normal functions slow down. Symptoms often develop gradually and may not be noticeable at first. Hypothyroidism is very common and is usually a lifelong condition. Fortunately, it can almost always be managed successfully with daily thyroid hormone replacement medication.

Learn More

Hypothyroidism – NIH MedlinePlus
https://medlineplus.gov/hypothyroidism.html

Provides easy-to-understand information about hypothyroidism, including symptoms, diagnosis, treatment, and long-term management.

Hypothyroidism (Underactive Thyroid) – American Thyroid Association
https://www.thyroid.org/hypothyroidism/

Explains what hypothyroidism is, why it develops, treatment options, and common questions.

How Common Is Hypothyroidism?

Hypothyroidism is one of the most common endocrine (hormone) disorders. It affects millions of people in the United States and is more common in women than men. The risk increases with age and in people with autoimmune diseases or a family history of thyroid disorders.

Learn More

American Thyroid Association – Hypothyroidism
https://www.thyroid.org/hypothyroidism/

Provides information about who is most likely to develop hypothyroidism and common risk factors.

What Symptoms Might You Notice?

What Symptoms Might You Notice?

Symptoms often develop slowly over months or years and can vary from person to person.

Common symptoms may include:

  • Fatigue
  • Weight gain
  • Feeling cold more easily
  • Dry skin
  • Constipation
  • Depression
  • Slow heart rate
  • Hair thinning or hair loss
  • Puffy face
  • Hoarse voice
  • Muscle aches or weakness
  • Joint pain
  • Memory problems or difficulty concentrating
  • Heavy or irregular menstrual periods

How Is Hypothyroidism Diagnosed?

Your healthcare provider will review your symptoms, perform a physical examination, and order blood tests to measure your thyroid hormone levels.

Most people are diagnosed using a combination of Thyroid-Stimulating Hormone (TSH) and Free T4 blood tests.

Learn More

Hypothyroidism – NIH MedlinePlus
https://medlineplus.gov/hypothyroidism.html

Explains how hypothyroidism is diagnosed and monitored.

Hypothyroidism infographic – click to enlarge

What Causes Hypothyroidism?

Several conditions can reduce thyroid hormone production.

Common causes include:

  • Hashimoto’s thyroiditis (Hashimoto’s disease), an autoimmune disorder and the most common cause
  • Previous thyroid surgery
  • Radioactive iodine treatment for hyperthyroidism
  • Radiation therapy involving the neck
  • Certain medications, such as lithium or amiodarone
  • Congenital hypothyroidism (present at birth)
  • Iodine deficiency (rare in the United States)

Learn More

Hypothyroidism – NIH MedlinePlus
https://medlineplus.gov/hypothyroidism.html

Learn about the common causes of hypothyroidism and risk factors.

What Can Make Hypothyroidism Worse?

Several factors can worsen symptoms or interfere with thyroid hormone treatment.

Common factors include:

  • Missing thyroid medication doses
  • Taking thyroid medication with food when instructed to take it on an empty stomach
  • Taking calcium or iron supplements too close to thyroid medication
  • Certain medications that interfere with thyroid hormone absorption
  • Untreated autoimmune disease
  • Pregnancy, which may increase thyroid hormone requirements

Learn More

American Thyroid Association
https://www.thyroid.org/

Provides practical guidance on taking thyroid medications correctly and managing hypothyroidism.

Prevention

Not all cases of hypothyroidism can be prevented, especially those caused by autoimmune diseases such as Hashimoto’s thyroiditis. However, early diagnosis and treatment can help prevent complications.

Helpful prevention tips include:

  • Take thyroid medication exactly as prescribed.
  • Attend regular healthcare appointments.
  • Have routine thyroid blood tests as recommended.
  • Eat a balanced diet with adequate iodine intake.
  • Inform your healthcare provider about new symptoms.
  • Follow recommendations for monitoring thyroid nodules if present.
  • Discuss any new medications or supplements with your healthcare provider.

Learn More

American Thyroid Association
https://www.thyroid.org/

Provides practical information about thyroid health, medication management, and long-term care.

Learn More About Hypothyroidism

The following video content is provided to help you better understand this condition. These resources are intended for educational purposes and should not replace personalized medical advice from your healthcare provider.

Labs

Laboratory testing is the primary way hypothyroidism is diagnosed and monitored.

Common laboratory tests may include:

  • Thyroid-Stimulating Hormone (TSH): The most important screening test for hypothyroidism.
  • Free T4 (Free Thyroxine): Measures the amount of circulating thyroid hormone.
  • Thyroid Peroxidase (TPO) Antibodies: Helps diagnose Hashimoto’s thyroiditis.
  • Complete Blood Count (CBC): May evaluate for anemia, which can contribute to fatigue.
  • Lipid Panel: Cholesterol levels are often elevated in untreated hypothyroidism.

Learn More

TSH Test – NIH MedlinePlus
https://medlineplus.gov/lab-tests/tsh-thyroid-stimulating-hormone-test/

Explains how TSH testing is used to diagnose and monitor hypothyroidism.

Diagnostics

Most people with hypothyroidism do not require imaging studies. However, additional testing may be recommended if thyroid enlargement or nodules are present.

Common diagnostic tests include:

  • Thyroid Ultrasound: Evaluates thyroid enlargement (goiter), nodules, or changes associated with Hashimoto’s thyroiditis.
  • Fine-Needle Aspiration (FNA) Biopsy: May be recommended if a thyroid nodule appears suspicious for cancer.
  • Radioactive Iodine Uptake Scan: Rarely needed for hypothyroidism but may be used when thyroid function is unclear.

Learn More

American Thyroid Association – Thyroid Function Tests
https://www.thyroid.org/thyroid-function-tests/

Provides information about thyroid blood tests, ultrasound, and thyroid nodule evaluation.

Treatment & Management

Treatment Options

Treatment focuses on replacing the thyroid hormone your body is unable to produce.

Treatment options may include:

  • Daily thyroid hormone replacement medication
  • Regular blood tests to monitor thyroid hormone levels
  • Medication dose adjustments based on laboratory results
  • Long-term follow-up with your healthcare provider

Learn More

Hypothyroidism – American Thyroid Association
https://www.thyroid.org/hypothyroidism/

Provides information about treatment options and long-term management of hypothyroidism.

Lifestyle Changes

Healthy lifestyle habits can support thyroid health and improve overall well-being.

Helpful lifestyle changes include:

  • Take thyroid medication exactly as prescribed.
  • Take thyroid medication on an empty stomach if instructed.
  • Wait the recommended amount of time before eating after taking your medication.
  • Eat a balanced diet.
  • Stay physically active.
  • Maintain a healthy weight.
  • Get enough sleep.
  • Keep regular healthcare appointments.
  • Report new or worsening symptoms to your healthcare provider.

Learn More

American Thyroid Association
https://www.thyroid.org/

Provides practical guidance for living well with hypothyroidism.

Medications

Most people with hypothyroidism are treated with thyroid hormone replacement medication.

Common medications include:

  • Levothyroxine: The standard treatment for hypothyroidism. It replaces the thyroid hormone your body is unable to produce.
  • Liothyronine (T3): May be prescribed in selected situations, although it is not routinely used for most people.
  • Combination T4/T3 Therapy: Occasionally recommended for selected patients under the guidance of an endocrinologist.

Learn More

Levothyroxine – NIH MedlinePlus
https://medlineplus.gov/druginfo/meds/a682461.html

Provides information about levothyroxine, proper use, side effects, and monitoring.

Procedures

Most people with hypothyroidism do not require surgery or invasive procedures. Treatment usually involves taking thyroid hormone replacement medication and having regular blood tests to monitor thyroid hormone levels. However, certain procedures may be recommended if thyroid nodules, an enlarged thyroid (goiter), or thyroid cancer is suspected.

Common procedures may include:

  • Thyroid Ultrasound: Uses sound waves to evaluate the size of the thyroid gland and detect nodules or enlargement.
  • Fine-Needle Aspiration (FNA) Biopsy: A small needle is used to collect cells from a thyroid nodule to determine if it is benign or cancerous.
  • Thyroidectomy: Surgical removal of part or all of the thyroid gland. This may be recommended for thyroid cancer, large goiters causing swallowing or breathing problems, or suspicious thyroid nodules.
  • Regular Thyroid Function Testing: Blood tests are routinely performed to ensure your medication dose is correct and your thyroid hormone levels remain within a healthy range.

Learn More

American Thyroid Association
https://www.thyroid.org/

Learn about thyroid ultrasound, biopsies, surgery, and long-term thyroid monitoring.

What Should You Expect Long-Term?

Hypothyroidism is usually a lifelong condition. With proper treatment, most people live healthy, active lives and experience significant improvement in their symptoms.

Your healthcare provider will monitor your thyroid hormone levels regularly and adjust your medication if needed. It is important to continue taking your medication every day, even if you feel well.

What Can You Do At Home?

Daily self-care is important for managing hypothyroidism and maintaining healthy thyroid hormone levels.

Helpful tips include:

  • Take your thyroid medication exactly as prescribed.
  • Take levothyroxine on an empty stomach with water unless instructed otherwise.
  • Wait at least 30–60 minutes before eating after taking your medication.
  • Avoid taking calcium or iron supplements within 4 hours of your thyroid medication unless directed by your healthcare provider.
  • Eat a balanced diet.
  • Stay physically active.
  • Get enough sleep.
  • Keep regular healthcare appointments.
  • Report new or worsening symptoms to your healthcare provider.

Learn More

Hypothyroidism – American Thyroid Association
https://www.thyroid.org/hypothyroidism/

Provides practical guidance on taking thyroid medication correctly and living with hypothyroidism.

Frequently Asked Questions

Will I need to take thyroid medication for life?

Most people with hypothyroidism require lifelong treatment with thyroid hormone replacement. Your healthcare provider will determine the best treatment plan based on the cause of your condition.

Can hypothyroidism cause weight gain?

Yes. Low thyroid hormone levels can slow your metabolism, making weight gain more likely. Treating hypothyroidism may help improve metabolism, although healthy eating and regular exercise remain important.

Can hypothyroidism cause fatigue?

Yes. Fatigue is one of the most common symptoms of hypothyroidism and often improves after treatment begins.

Can I take my thyroid medication with other medications?

Some medications and supplements, especially calcium and iron, can interfere with thyroid hormone absorption. Always ask your healthcare provider or pharmacist how to take your medications correctly.

How often should my thyroid levels be checked?

Thyroid blood tests are commonly checked 6–8 weeks after starting or changing medication and then periodically once your levels are stable.

Questions To Ask Your Provider

Consider asking your healthcare provider:

  • What is causing my hypothyroidism?
  • Will I need thyroid medication for life?
  • How should I take my medication?
  • How often should my thyroid levels be checked?
  • Are any of my other medications affecting my thyroid medication?
  • Do I have thyroid nodules that need monitoring?
  • When should I schedule my next follow-up appointment?

Specialist Referrals

Many people with hypothyroidism receive care from their primary care provider. Depending on your condition, your provider may recommend seeing a specialist.

You may be referred to:

  • Endocrinologist: Specializes in thyroid disorders and other hormone-related conditions.
  • Endocrine Surgeon: Evaluates thyroid nodules, large goiters, or thyroid cancer that may require surgery.
  • Registered Dietitian: Provides nutrition guidance for maintaining a healthy weight and supporting overall wellness.

Learn More

American Thyroid Association
https://www.thyroid.org/

Provides patient education about thyroid disorders, specialists, and treatment options.

Is Hypothyroidism Curable?

Most cases of hypothyroidism are not curable, particularly when caused by Hashimoto’s thyroiditis, the most common cause. However, hypothyroidism is highly treatable with daily thyroid hormone replacement medication.

Most people experience significant improvement in symptoms once thyroid hormone levels return to a normal range, and many live healthy, active lives with ongoing treatment.

Emergency Symptoms / When To Seek Immediate Help

Call 911 or seek emergency medical care immediately if you experience:

  • Severe difficulty breathing
  • Chest pain
  • Loss of consciousness
  • Severe confusion
  • Very low body temperature
  • Extreme drowsiness or inability to wake up
  • Slow heart rate with severe weakness

These symptoms may be signs of myxedema coma, a rare but life-threatening complication of severe untreated hypothyroidism.

Seek prompt medical evaluation if you notice:

  • Rapidly worsening fatigue
  • Significant swelling of the neck
  • Difficulty swallowing
  • Persistent hoarseness
  • New or worsening symptoms despite taking your medication

Learn More

Hypothyroidism – NIH MedlinePlus
https://medlineplus.gov/hypothyroidism.html

Learn about hypothyroidism, possible complications, and when emergency medical care is needed.

CALL 911

APNS does not provide emergency medical services. If you believe you are experiencing a medical emergency, including (but not limited to) chest pain, difficulty breathing, stroke symptoms, severe allergic reactions, anaphylaxis, uncontrolled bleeding, seizures, loss of consciousness, or any other potentially life-threatening condition, you are instructed to call 911 immediately or go immediately to the nearest emergency department.

Official Resources / External Links

Hypothyroidism – NIH MedlinePlus
https://medlineplus.gov/hypothyroidism.html

Easy-to-understand information about hypothyroidism, including symptoms, diagnosis, treatment, and living with an underactive thyroid.

American Thyroid Association – Hypothyroidism
https://www.thyroid.org/hypothyroidism/

Comprehensive patient education about hypothyroidism, thyroid hormone replacement, laboratory monitoring, and frequently asked questions.

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
https://www.niddk.nih.gov/health-information/endocrine-diseases

Reliable information about thyroid disease and other endocrine disorders.

Hormone Health Network
https://www.hormone.org/

Evidence-based patient education about thyroid disorders, hormone health, and endocrine conditions.

This guide is intended for educational purposes only and should not replace medical advice, diagnosis, or treatment from your healthcare provider. Always follow the recommendations of your healthcare team regarding your individual health needs. Contact your healthcare provider if your symptoms worsen, new symptoms develop, or your medication is no longer controlling your hypothyroidism. Call 911 immediately if you experience severe difficulty breathing, chest pain, loss of consciousness, severe confusion, or symptoms of myxedema coma or another medical emergency.

Get personalized care for Hypothyroidism

At APNS, our providers take the time to understand your condition and your goals. We offer comprehensive telehealth visits at a fixed rate — no membership fees, no insurance required, and no unexpected charges. Whether you’re newly diagnosed or looking for a provider who actually listens, we’re here to help.